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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMPDL3B
All Species:
24.55
Human Site:
Y176
Identified Species:
49.09
UniProt:
Q92485
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92485
NP_001009568.1
455
50814
Y176
L
F
K
K
G
A
F
Y
C
E
K
L
P
G
P
Chimpanzee
Pan troglodytes
XP_001151336
455
50854
Y176
L
F
K
K
G
A
F
Y
C
E
K
L
P
G
P
Rhesus Macaque
Macaca mulatta
XP_001108274
453
51294
T186
L
D
E
E
A
I
S
T
L
R
K
G
G
F
Y
Dog
Lupus familis
XP_544464
468
52011
Y188
L
F
K
Q
G
A
F
Y
S
E
K
L
P
G
L
Cat
Felis silvestris
Mouse
Mus musculus
P58242
456
51581
Y176
L
F
K
R
G
A
F
Y
S
E
K
L
P
G
P
Rat
Rattus norvegicus
Q641Z7
445
49877
I181
P
W
L
D
E
E
A
I
S
T
L
R
K
G
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516772
436
49539
Y155
T
L
R
K
G
G
F
Y
S
Q
T
L
P
S
N
Chicken
Gallus gallus
XP_001232192
454
51318
Y172
L
F
R
A
G
A
F
Y
S
E
K
L
P
S
P
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_692822
457
52265
Y179
T
F
K
T
G
G
Y
Y
T
E
K
L
L
N
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_729555
488
55653
M178
V
A
L
N
T
N
F
M
R
L
D
P
D
P
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_505620
755
86279
Y173
T
F
L
K
G
G
Y
Y
K
Y
R
L
R
N
A
Sea Urchin
Strong. purpuratus
XP_786766
452
51341
G180
N
D
T
F
K
S
G
G
Y
Y
V
T
P
I
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
40.2
76.2
N.A.
75.6
39.3
N.A.
38
61
N.A.
54.2
N.A.
28.6
N.A.
23.8
39.3
Protein Similarity:
100
99.5
58
83.9
N.A.
86.1
58.4
N.A.
55.8
74
N.A.
71.1
N.A.
47.9
N.A.
37
58
P-Site Identity:
100
100
13.3
80
N.A.
86.6
6.6
N.A.
40
73.3
N.A.
46.6
N.A.
6.6
N.A.
33.3
6.6
P-Site Similarity:
100
100
26.6
86.6
N.A.
93.3
13.3
N.A.
53.3
80
N.A.
53.3
N.A.
13.3
N.A.
46.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
0
9
9
42
9
0
0
0
0
0
0
0
9
% A
% Cys:
0
0
0
0
0
0
0
0
17
0
0
0
0
0
0
% C
% Asp:
0
17
0
9
0
0
0
0
0
0
9
0
9
0
9
% D
% Glu:
0
0
9
9
9
9
0
0
0
50
0
0
0
0
0
% E
% Phe:
0
59
0
9
0
0
59
0
0
0
0
0
0
9
0
% F
% Gly:
0
0
0
0
67
25
9
9
0
0
0
9
9
42
9
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
9
0
9
0
0
0
0
0
9
0
% I
% Lys:
0
0
42
34
9
0
0
0
9
0
59
0
9
0
0
% K
% Leu:
50
9
25
0
0
0
0
0
9
9
9
67
9
0
9
% L
% Met:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% M
% Asn:
9
0
0
9
0
9
0
0
0
0
0
0
0
17
17
% N
% Pro:
9
0
0
0
0
0
0
0
0
0
0
9
59
9
34
% P
% Gln:
0
0
0
9
0
0
0
0
0
9
0
0
0
0
9
% Q
% Arg:
0
0
17
9
0
0
0
0
9
9
9
9
9
0
0
% R
% Ser:
0
0
0
0
0
9
9
0
42
0
0
0
0
17
0
% S
% Thr:
25
0
9
9
9
0
0
9
9
9
9
9
0
0
0
% T
% Val:
9
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% V
% Trp:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
17
67
9
17
0
0
0
0
9
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _